短语讲解：

1. Economic conditions in the U.S. began to worsen at that time.

at that time 当时; 在那时
例句：At that time, financing for new cars was just coming into its own.
当时，新车贷款办法刚刚流行。

2. This can give long-term treatment time to take effect.

take effect 生效，奏效
例句：The new regulations will take effect tomorrow.
新的规定明天开始生效。

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