What do you mean? 你什么意思？接下来讲解。
例句：

1. Iris：What do you mean by that?
艾瑞丝：你那样说是什么意思？

2. What do you mean by saying so?
你这么说什么意思?

3.What do you mean we have no more milk. I just bought some yesterday.
我们的牛奶又没了，你什么意思，我昨天刚买的。