Nadal, 23, lost his first ever match at Roland Garros last year when he fell to Sweden Robin Soderling in the round of 16.

Starting freshly this season with three titles on clay, Nadal booked a last 16 clash with 24th seed Thomaz Bellucci.

"He's top level opponent," Nadal commented on his next rival. " The last time I played him he was very difficult. He's a clay specialist. "

The women's singles top seed Serena Williams overcame illness and a bad second set to defeat Russian hopeful Anastasia Pavlyuchenkova 6-1, 1-6, 6-2.

Andy Roddick of the United States celebrates his victory over Blaz Kavcic of Serbia during the men's singles second round match at the French Open tennis championship in Paris, France, on May 27 2010. Roddick won by 3-1.

The 12-time Grand Slam champion asked doctor to check her condition after 5-0 down and took some pills.

"I just ran out of a little energy out there. Just fighting a cold and fighting sickness," said Williams.

The 12nd seed Maria Sharapova from Russia and four time French Open champion Justine

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